Xoe, an innovative respelling of the classical Greek name Zoe (from ζῴη, “life”), unfolds as a distinctive feminine appellation within the continuum of Hellenic and Latin onomastic traditions. Pronounced ZOH (/zoʊ/) in English, this variant retains its ancient semantic charge of vitality while introducing an avant-garde orthographic flourish that resonates with Romance-language sensibilities and subtly evokes the Latin vita. A quantitative survey of U.S. Social Security records traces Xoe’s emergence in the late 1990s—initially rare, it reached a zenith at rank 902 (60 occurrences) in 2009 before stabilizing in the top 1,000 with 26 newborns and rank 924 in 2024—thereby illustrating a pattern of measured yet enduring appeal. The substitution of the initial X, often perceived as exotic within Latin-derived tongues, underscores a strategic blend of historical gravitas and contemporary individuality. Through its compact syllabic form and scholarly resonance, Xoe presents a harmonious confluence of classical heritage and modern creativity—a name that encapsulates life’s perennial energy with both precision and panache.